SrasV1, Main, Exploration, bibRecord, 002935

Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus

Identifieur interne : 002935 ( Main/Exploration ); précédent : 002934; suivant : 002936

Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus

Auteurs : MENG YU [Australie] ; Mary Tachedjian [Australie] ; Gary Crameri [Australie] ; ZHENGLI SHI [République populaire de Chine] ; Lin-Fa Wang [Australie]

Source :

Journal of general virology [ 0022-1317 ] ; 2010.

RBID : Pascal:10-0421872

Descripteurs français

Pascal (Inist)
- Coronavirus, Identification, Angiotensine I, Enzyme, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Enzyme.

English descriptors

KwdEn :
- Angiotensin I, Coronavirus, Enzyme, Identification, Severe acute respiratory syndrome.

Abstract

Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40-42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000138
to stream PascalFrancis, to step Curation: 000850
to stream PascalFrancis, to step Checkpoint: 000144
to stream Main, to step Merge: 002976
to stream Main, to step Curation: 002935

Le document en format XML

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<front><div type="abstract" xml:lang="en">Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40-42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.</div>
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Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus

Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri